October 25, 2021

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Kansas City Chiefs at New Orleans Saints odds, picks and prediction

The Kansas City Chiefs (12-1) visit the New Orleans Saints (10-3) Sunday for a 4:25 p.m. ET kickoff at Mercedes-Benz Superdome. Below, we preview the Chiefs-Saints betting odds and lines and make our NFL picks and predictions.

Chiefs at Saints: Betting odds, spread and lines

Odds via BetMGM; access USA TODAY Sports’ betting odds for a full list. Lines last updated Saturday at 5:20 p.m. ET.

  • Money line: Chiefs -165 (bet $165 to win $100) | Saints +140 (bet $100 to win $140)
  • Against the spread/ATS: Chiefs -3 (-115) | Saints +3 (-105)
  • Over/Under: 52.5 (O: -110 | U: -110)

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Chiefs at Saints: Game notes

  • The Chiefs are coming off a 33-27 road victory against the Miami Dolphins, an AFC playoff hopeful team. It wasn’t a very clean game, though, especially for QB Patrick Mahomes, who tossed an uncharacteristic three interceptions.
  • While Mahomes made some rare miscues vs. Miami, he also threw for 393 yards and two touchdowns, while averaging a season-high 11.6 yards per attempt. He has six straight 300-yard games heading into New Orleans.
  • The Chiefs have won eight consecutive games since their lone setback at home to the Las Vegas Raiders in Week 5. However, Kansas City has failed to cover in its past five games. More surprisingly, the Under actually has hit more for the Chiefs this season, going 7-6.
  • New Orleans will welcome back QB Drew Brees (ribs, lung) after a four-game absence. He was knocked out of the Saints’ Week 10 win against the San Francisco 49ers with fractured ribs and a punctured lung.
  • The Saints are coming off a disappointing 24-21 road loss at the Philadelphia Eagles, snapping a nine-game win streak and five-game cover run. Their defense had also allowed 16 or fewer points in each of the past five, and New Orleans was on a 5-0 Under run.
  • New Orleans is 2-1 straight-up against the AFC West this season but just 1-2 ATS. The Saints won their lone home game against the division, but it was a 30-27 struggle in overtime against the Los Angeles Chargers back in Week 5 on a Monday night.

Chiefs at Saints: Key injuries

Chiefs

  • OT Eric Fisher (back) questionable
  • OL Mike Remmers (back, neck) out
  • RB Darwin Thompson (illness) out
  • LB Damien Wilson (knee) out

Saints

  • DT Malcom Brown (shoulder, calf) out
  • OG Nick Easton (concussion) out
  • WR Deonte Harris (neck) questionable
  • WR Michael Thomas (ankle) out

Chiefs at Saints: Odds, betting lines, predictions and picks

Prediction

Chiefs 33, Saints 30

Money line (?)

It’s rare when I play money lines in the NFL, but I like the CHIEFS (-165) in this one. This has the potential to be a one-possession game decided by a late Harrison Butker field goal, actually.

Against the spread (?)

The Chiefs -3 (-115) isn’t a terrible play. It would be my lean if I were forced to pick against the spread. As stated above, I believe this one is decided by a field goal, so it would be a push if we played KC -3. PASS.

Over/Under (?)

OVER 52.5 (-110) is the play in this potential shootout. Brees is healthy just in time to give the Sunday late-window national audience what it wants. We get the young superstar Mahomes against the future Hall of Famer Brees in a clash that has the potential to be epic. Attention: Scoreboard operator in NOLA, be ready!

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